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pentobarbital will lessen the level or outcome of efavirenz by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.pentobarbital raises effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Observe. Coadministration of ifosfamide with CYP2B6 inducers may perhaps maximize metabolism of ifo